Paraquat Toxicity: Proposed Mechanism of Action Involving Lipid Peroxidation
نویسندگان
چکیده
منابع مشابه
Paraquat toxicity: proposed mechanism of action involving lipid peroxidation.
The purpose of this study was to investigate the hypothesis that paraquat pulmonary toxicity results from cyclic reduction-oxidation of paraquat with sequential generation of superoxide radicals and singlet oxygen and initiation of lipid peroxidation. In vitro mouse lung microsomes catalyzed an NADPH-dependent, single-electron reduction of paraquat. Incubation of paraquat with NADPH, NADPH-cyto...
متن کاملAlternative electron acceptors: Proposed mechanism of paraquat mitochondrial toxicity.
Paraquat (PQ) is a relatively safe and effective herbicide used all over the world. PQ is very toxic to all living organisms; and many cases of acute poisoning and death have been reported over the past decade. The main suggested potential mechanism for PQ toxicity is the production of superoxide radicals from the metabolism of the PQ by microsomal enzyme systems, and by inducing mitochondrial ...
متن کاملA mechanism of paraquat toxicity involving nitric oxide synthase.
Paraquat (PQ) is a well described pneumotoxicant that produces toxicity by redox cycling with cellular diaphorases, thereby elevating intracellular levels of superoxide (O-(2)). NO synthase (NOS) has been shown to participate in PQ-induced lung injury. Current theory holds that NO reacts with O-(2) generated by PQ to produce the toxin peroxynitrite. We asked whether NOS might alternatively func...
متن کاملHuman placental lipid peroxidation--II. NADPH and iron dependent stimulation of microsomal lipid peroxidation by paraquat.
Paraquat, a widely used herbicide, was found to cause a marked stimulation of lipid peroxidation in the human placental microsomes in vitro. Both NADPH and chelated iron were necessary to observe paraquat-stimulated lipid peroxidation. The malondialdehyde accumulation in the incubation medium increased with increase in time, protein and paraquat concentration. The reaction did not exhibit the i...
متن کاملInvestigation of lipid peroxidation as probable mechanism of rifampicin toxicity in vivo
BACKGROUND Xenobiotics may exert their toxic effects on tissues directly or after they have been metabolized. Increased reactivity of xenobiotics owing to their conversion to electrophiles, free radicals, nucleophiles and redox-active reactants may also contribute to toxicity. PURPOSE The present study attempts to investigate the possible "lipid peroxidation/free radical generation" mechanism...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1976
ISSN: 0091-6765
DOI: 10.2307/3428594